Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (34): 5572-5576.doi: 10.3969/j.issn.2095-4344.2014.34.028

Previous Articles    

Tissue patch for prevention of dry socket after extraction of the mandibular molars: a sysrematic review

Lu Qun, Huang Yi, Kong Ling-ying   

  1. Department of Stomatology, Chengdong Branch, Sichuan Provincial People’s Hospital, Chengdu 610110, Sichuan Province, China
  • Revised:2014-07-31 Online:2014-08-20 Published:2014-08-20
  • Contact: Huang Yi, M.D., Attending physician, Department of Stomatology, Chengdong Branch, Sichuan Provincial People’s Hospital, Chengdu 610110, Sichuan Province, China
  • About author:Lu Qun, Associate chief physician, Department of Stomatology, Chengdong Branch, Sichuan Provincial People’s Hospital, Chengdu 610110, Sichuan Province, China

Abstract:

BACKGROUND: Tissue patch is used to increase bone mass after mandibular molar extraction, which is conducive to late-stage repair, but it is unexpectedly found that after implantation of tissue patch, incidence of dry socket is significantly reduced.

OBJECTIVE: To assess the efficacy of tissue patch for the control of dry socket caused by mandibular molar extraction via the method of systematic review.
METHODS: MEDLINE (OVID), CENTRAL, EMBASE and CBM were searched for clinical randomized controlled trials and clinical controlled trials. The keywords were “dry socket, tissue patch, acellular dermis matrix, tooth extraction” in English and Chinese. The references of the included studies and 19 Chinese dental journals were hand-searched. Two reviewers independently assessed the risk of bias using Cochrane Collaboration’s tool, and extracted data. Meta-analysis was delivered with Revman 5.1.
RESULTS AND CONCLUSION: Eight studies, including five randomized controlled trials and three clinical controlled trials, were included. Totally 2 052 participants were involved. Seven of the included studies had moderate risk of bias and one had high risk of bias. Meta analysis showed that implantation of the tissue patch into the extraction socket could reduce 86% of the risk of dry socket (relative risk=0.14, 95% confidence interval [0.08, 0.26], P < 0.000 01). Sensitivity analysis showed that this outcome was relatively stable. Implantation of tissue patch into extraction socket could significantly reduce the risk of dry socket, but more randomized controlled trials are needed.

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

Key words: dry socket, tooth extraction, meta-analysis

CLC Number: